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Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome
Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We …
Matthew Rendina
,
Peter J. Turnbaugh
,
Patrick H. Bradley
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Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses
Individual genes from microbiomes can drive host-level phenotypes. To help identify such candidate genes, several recent tools estimate …
Stephanie N. Majernik
,
Larry Beaver
,
Patrick H. Bradley
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Framework for exploring the sensory repertoire of the human gut microbiota
Bacteria sense changes in their environment and transduce signals to adjust their cellular functions accordingly. For this purpose, …
Patricia A. Ross
,
Wenhao Xu
,
Ekaterina Jalomo-Khayrova
,
Gert Bange
,
Vadim M. Gumerov
,
Patrick H. Bradley
,
Victor Sourjik
,
Igor B. Zhulin
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DOI
Proteobacteria explain significant functional variability in the human gut microbiome
BACKGROUND While human gut microbiomes vary significantly in taxonomic composition, biological pathway abundance is surprisingly …
Patrick H. Bradley
,
Katherine S. Pollard
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