Humans

Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome
Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We …
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Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses
Individual genes from microbiomes can drive host-level phenotypes. To help identify such candidate genes, several recent tools estimate …
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Framework for exploring the sensory repertoire of the human gut microbiota
Bacteria sense changes in their environment and transduce signals to adjust their cellular functions accordingly. For this purpose, …
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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is …
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Phylogeny-corrected identification of microbial gene families relevant to human gut colonization
The mechanisms by which different microbes colonize the healthy human gut versus other body sites, the gut in disease states, or other …
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Proteobacteria explain significant functional variability in the human gut microbiome
BACKGROUND While human gut microbiomes vary significantly in taxonomic composition, biological pathway abundance is surprisingly …
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Automated and accurate estimation of gene family abundance from shotgun metagenomes
Shotgun metagenomic DNA sequencing is a widely applicable tool for characterizing the functions that are encoded by microbial …
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