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Framework for exploring the sensory repertoire of the human gut microbiota
Bacteria sense changes in their environment and transduce signals to adjust their cellular functions accordingly. For this purpose, …
Patricia A. Ross
,
Wenhao Xu
,
Ekaterina Jalomo-Khayrova
,
Gert Bange
,
Vadim M. Gumerov
,
Patrick H. Bradley
,
Victor Sourjik
,
Igor B. Zhulin
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DOI
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is …
Peter Spanogiannopoulos
,
Than S. Kyaw
,
Ben G. H. Guthrie
,
Patrick H. Bradley
,
Joyce v. Lee
,
Jonathan Melamed
,
Ysabella Noelle Amora Malig
,
Kathy N. Lam
,
Daryll Gempis
,
Moriah Sandy
,
Wesley Kidder
,
Erin L. Van Blarigan
,
Chloe E. Atreya
,
Alan Venook
,
Roy R. Gerona
,
Andrei Goga
,
Katherine S. Pollard
,
Peter J. Turnbaugh
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DOI
Phylogeny-corrected identification of microbial gene families relevant to human gut colonization
The mechanisms by which different microbes colonize the healthy human gut versus other body sites, the gut in disease states, or other …
Patrick H. Bradley
,
Stephen Nayfach
,
Katherine S. Pollard
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Proteobacteria explain significant functional variability in the human gut microbiome
BACKGROUND While human gut microbiomes vary significantly in taxonomic composition, biological pathway abundance is surprisingly …
Patrick H. Bradley
,
Katherine S. Pollard
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DOI
Automated and accurate estimation of gene family abundance from shotgun metagenomes
Shotgun metagenomic DNA sequencing is a widely applicable tool for characterizing the functions that are encoded by microbial …
Stephen Nayfach
,
Patrick H. Bradley
,
Stacia K. Wyman
,
Timothy J. Laurent
,
Alex Williams
,
Jonathan A. Eisen
,
Katherine S. Pollard
,
Thomas J. Sharpton
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