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Framework for exploring the sensory repertoire of the human gut microbiota
Bacteria sense changes in their environment and transduce signals to adjust their cellular functions accordingly. For this purpose, …
Patricia A. Ross
,
Wenhao Xu
,
Ekaterina Jalomo-Khayrova
,
Gert Bange
,
Vadim M. Gumerov
,
Patrick H. Bradley
,
Victor Sourjik
,
Igor B. Zhulin
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DOI
Proteobacteria explain significant functional variability in the human gut microbiome
BACKGROUND While human gut microbiomes vary significantly in taxonomic composition, biological pathway abundance is surprisingly …
Patrick H. Bradley
,
Katherine S. Pollard
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Automated and accurate estimation of gene family abundance from shotgun metagenomes
Shotgun metagenomic DNA sequencing is a widely applicable tool for characterizing the functions that are encoded by microbial …
Stephen Nayfach
,
Patrick H. Bradley
,
Stacia K. Wyman
,
Timothy J. Laurent
,
Alex Williams
,
Jonathan A. Eisen
,
Katherine S. Pollard
,
Thomas J. Sharpton
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Yeast cells can access distinct quiescent states
We conducted a phenotypic, transcriptional, metabolic, and genetic analysis of quiescence in yeast induced by starvation of …
Maja M Klosinska
,
Christopher a Crutchfield
,
Patrick H Bradley
,
Joshua D Rabinowitz
,
James R Broach
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Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations
Microbes tailor their growth rate to nutrient availability. Here, we measured, using liquid chromatography-mass spectrometry, …
Viktor M. Boer
,
Christopher A. Crutchfield
,
Patrick H. Bradley
,
David Botstein
,
Joshua D. Rabinowitz
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