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Anaerobic riboflavin degradation by human gut Lachnospiraceae
Vitamins mediate a web of cross-feeding interactions in the human gut. Many gram-positive gut microbes, in particular, are predicted to …
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Optimizing strain selection for association studies under hard cost constraints
Quantitative genetics methods linking genotype to phenotype are powerful tools in model organisms and nonhuman populations, allowing …
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Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome
Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We …
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Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses
Individual genes from microbiomes can drive host-level phenotypes. To help identify such candidate genes, several recent tools estimate …
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Adaptive adjustment of significance thresholds produces large gains in microbial gene annotations and metabolic insights
Gene function annotations enable microbial ecologists to make inferences about metabolic potential from genomes and metagenomes. …
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Framework for exploring the sensory repertoire of the human gut microbiota
Bacteria sense changes in their environment and transduce signals to adjust their cellular functions accordingly. For this purpose, …
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Four-part harmony between diet, drugs, microbes, and host
In this issue of Cell Host & Microbe, Zeng et al. show that a specific gut microbe causes diet-dependent attenuation of …
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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is …
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Building a chemical blueprint for human blood
What determines the chemical make-up of human blood? Measurement of the contributions of factors ranging from genetics to lifestyle has …
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phylogenize: correcting for phylogeny reveals genes associated with microbial distributions
Phylogenetic comparative methods are powerful but presently under-utilized ways to identify microbial genes underlying differences in …
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