Lachnospiraceae

Anaerobic riboflavin degradation by human gut Lachnospiraceae
Vitamins mediate a web of cross-feeding interactions in the human gut. Many gram-positive gut microbes, in particular, are predicted to …
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Optimizing strain selection for association studies under hard cost constraints
Quantitative genetics methods linking genotype to phenotype are powerful tools in model organisms and nonhuman populations, allowing …
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A robust, sensitive phylogenetic method enables gene-level metagenomic analyses
A key goal in the microbiome field is to move from taxonomic associations towards mechanistic hypotheses about microbial gene function. …
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Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome
Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We …
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Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses
Individual genes from microbiomes can drive host-level phenotypes. To help identify such candidate genes, several recent tools estimate …
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Adaptive adjustment of significance thresholds produces large gains in microbial gene annotations and metabolic insights
Gene function annotations enable microbial ecologists to make inferences about metabolic potential from genomes and metagenomes. …
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Berry Supplement-Modified Human Microbiome Improves Immunotherapy Response in Mouse Models
Cancer outcomes have improved with immune checkpoint inhibitor (ICI) treatment; however, less than half of tumors respond. Emerging …
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